The Contractor shall exert his best efforts to use a refined morphological classification of human mammary carcinoma and apply this to seek correlations between epidemiologic risk factors and various histopathologic subentities of breast cancer. This will hopefully serve as a first step in elucidating our understanding of the role such morphologic patterns may play in the etiology and prognosis of this disease. The chief emphasis of this study will be the identification of markers for the identification of familial breast cancer in each of the specific risk groups identified by Dr. David Anderson. An ultimate objective is the characterization of various subgroups of breast cancer patients by multiple criteria both clinical and histologic.